PTGS2 and neoplasm: In addition, despite early ferroptotic tumor cells were found to release DAMPs, these antigens failed to promote dendritic cells (DCs) maturation due to the elevated gene expression of cyclooxygenase 2 (COX-2) [16] and prostaglandin E2 (PGE2) [17], which suppress the activity of anti-tumor T-helper cells and enhance immunosuppressive Tregs and MDSCs [18, 19].