Jeffery et al., in 2017, investigated the effects of very low dose IL-2 the subsequent survival and function of TReg and T effector cells from the blood and livers of patients with autoimmune liver diseases associated with increased expression of FoxP3+ and CD25+ and the anti-apoptotic protein Bcl-2 in Treg [45]. This evidence concerns the gene BCL2 and autoimmune hepatitis.