IL2 and Hyperkeratosis: Groups treated with betamethasone showed mild improvement (P-value ≤ 0.005) in parakeratosis, acanthosis, hyperkeratosis, and lymphocyte infiltration as shown in Fig. 5E and F. A low dose of IL-2 group showed the moderate improvement in parakeratosis, acanthosis, hyperkeratosis, and lymphocyte infiltration (P-value ≤ 0.005) as shown in Fig. 5G and H. Scaling of the skin is often an indication of parakeratosis, that is, altered epidermal differentiation, a phenomenon typical for psoriasis skin lesions.