Since the whole in vitro experiments are conducted using HUVEC, and the adult vascular endothelial cells exhibit anatomical heterogeneity; thus, the use of other type of EC may help us assess the role of NAT10 in hypertension in the future (Tan et al. 2004; Medina-Leyte et al. 2020).The other limitations of this study include the use of only male animals, so the results may not be directly generalizable to female individuals. The gene discussed is NAT10; the disease is hypertensive disorder.