Multiple groups have identified spatial learning and memory deficits induced by CIH based on reductions in behavioral performance, postsynaptic density, and long-term potentiation in the hippocampus in two separate AD model paradigms: APP/PS1 mice after 2 weeks of CIH treatment and a tau mouse model after 8 weeks of CIH exposure [67, 68]. This evidence concerns the gene MAPT and Alzheimer disease.