Notably, patients with NSCLC with upregulated PYCR1 expression exhibited the substantial enrichment of gene sets related to EGFR-associated pathways compared with patients with downregulated PYCR1 expression (Fig. 2a), supposing a functional association between PYCR1 and EGFR signaling in NSCLC. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.