Importantly, treatment with 10 μM PYCR1-IN-1 significantly reduced the size of EGFR- or TLR-induced tumor spheroids in H1299, H460, A549, H358 cells compared with cells treated with EGF or TLR agonists alone (Fig. 8b–g and Supplementary Fig. 10a,b). Here, PYCR1 is linked to neoplasm.