EGFR and neoplasm: Importantly, treatment with 10 μM PYCR1-IN-1 significantly reduced the size of EGFR- or TLR-induced tumor spheroids in H1299, H460, A549, H358 cells compared with cells treated with EGF or TLR agonists alone (Fig. 8b–g and Supplementary Fig. 10a,b).