Moreover, the association study between PYCR1 and EGFR expression in patients with NSCLC remarkably showed that gene sets related to cancer modules, cancer progression and EGFR signals were highly enriched in 20 patients with PYCR1upEGFRup NSCLC as compared with those of 3 patients with PYCR1downEGFRdown NSCLC (Supplementary Table 2 and Supplementary Fig. 4a–q). This evidence concerns the gene PYCR1 and non-small cell lung carcinoma.