The cytotoxic function of NK cells against tumor cells is frequently contingent upon the expression of diverse NK cell surface receptors, particularly activating receptors including CD226 (also referred to as DNAM-1), NKG2D, and natural cytotoxicity receptors (NCRs), which encompass NKp30, NKp44, and NKp46. The gene discussed is KLRK1; the disease is neoplasm.