ARHGAP35 and breast cancer: Given its role in actin dynamics and cell motility and based on our previous reports indicating an association between cell-ploidy control and actin dynamics30,31 it is intriguing to investigate if p190A contributes to chromosome stability of urothelial cells, and whether p190A has a role in BC progression by influencing the invasive and migratory capacities of BC cells through actin dynamics.