From neuroblastoma patient datasets, high HMMR expression can mark tumours as higher risk and HMMR expression represents a risk factor independent of MYCN. Although HMMR is an HA receptor, other HA-signaling genes, including CD44, do not show prognostic significance, suggesting that HA signaling per se may not be a sufficient influence behind HMMR’s pro-oncogenic actions in these tumours. Here, MYCN is linked to neuroblastoma.