These results are reminiscent of the phenotype of Atp13a2 KO mice since these mice do not exhibit nigrostriatal pathway dopaminergic neurodegeneration or α-syn pathology up to 27 months of age, indicating that constitutive Atp13a2 KO alone is insufficient to replicate PD-like neuropathology30,56, nicely reviewed in ref. 15. The gene discussed is ATP13A2; the disease is Parkinson disease.