ATP13A2 and Kufor-Rakeb syndrome: Recently, a mouse with conditional deletion of Atp13a2 in the SN31 and a non-human primate model where ATP13A2 expression was impaired by virally-delivered shATP13A232 were reported to replicate a phenotype close to that observed in human KRS patients, with nigrostriatal neurodegeneration, neuroinflammation, and dysfunction of the autophagy-lysosomal pathway (ALP)33.