ATP13A2 and Parkinson disease: To determine whether loss of ATP13A2 may underlie PD-linked lysosomal alterations, we first quantified the density of lysosomes, autophagosomes, early- and late-autolysosomes, multivesicular bodies, and mitochondria in dopaminergic neurons of the SN of 6- (Fig. 5a) and 12mo rats (Fig. 5b), through electron microscopy examination.