Given that the parotid gland is the most common site of AdCC (8/14, 57%) and that proximity to facial nerve perineural invasion is a common result of AdCC, the overexpression of XIAP in the parotid gland in AdCC may be due to the “low-resistance” hypothesis, which views the perineural space as a low-resistance channel through which neoplastic cells can easily spread along the nerve6. Here, XIAP is linked to adrenocortical carcinoma, hereditary.