ALX3 and frontonasal dysplasia: For instance, Alx3 and Pax7, early positional marker genes of the MNP and LNP in mouse, respectively, are linked to the abnormal facial shape features observed in homologous areas in the human face, such as frontonasal dysplasia and non-syndromic cleft lip, respectively (Fig. 7E–G; Supp.