Furthermore, the T cell interactions in MDS differed quite dramatically from Control and CHIP where Adipo-CARs interacted with all CD4/CD8 populations: mostly with Tregs, CD4naive/CM, and CD4 mixed cells in CHIP, while in MDS, their interactions were primarily with IFN-responsive T cells and CD4EM cells (Fig. 6H). Here, CD8A is linked to myelodysplastic syndrome.