This is corroborated by the reduced expression of adipocyte-specific markers (ACACA, FABP4) in the NanoString MDS data (Fig. 1E), and by histological analysis, showing a significant reduction of BM adipocytes in MDS (Fig. 3B, C, and Supplementary Fig. 5A–C). The gene discussed is ACACA; the disease is myelodysplastic syndrome.