A UMAP representation followed by broad cell type classification revealed the expected 3 major compartments: 1,396 stromal cells (CXCL12 and LEPR), 9,962 T cells (CD3E and CD247), and 12,257 HSPCs (CD34 and SPINK2) (Fig. 2B), along with a small population of CD14-low monocytes, which was unexpectedly recovered from MDS donors despite CD14- gating. This evidence concerns the gene SPINK2 and myelodysplastic syndrome.