Three distinct T cell populations were significantly differentially abundant in Controls: Heat Shock Protein (HSP)﻿+﻿ T cells were elevated in CHIP and MDS, while IFN-responsive and cytotoxic CD8+ TEMRA/TEFF cells were specifically enriched in MDS (Fig. 6A, Supplementary Fig. 4J). This evidence concerns the gene IFNA1 and myelodysplastic syndrome.