In contrast, both IFN-responsive and cytotoxic CD8+﻿﻿﻿﻿﻿﻿﻿﻿﻿﻿﻿﻿﻿﻿﻿﻿﻿﻿﻿﻿﻿﻿﻿﻿ cells were recently associated with exacerbated inflammation in autoimmune diseases such rheumatoid arthritis93–95. The gene discussed is CD8A; the disease is autoimmune disease.