Similarly, although no previous study has looked into the prevalence of orthostatic hypotension among p.R1628P carriers, studies of other LRRK2 variants (involving p.G2019S and p.R1441G) have shown that autonomic dysfunction, including orthostatic hypotension, which is thought to reflect more widespread synucleinopathy affecting the nervous system77, is less common than in idiopathic PD8,78. Here, LRRK2 is linked to Abnormal autonomic nervous system physiology.