The frequency of these LRRK2 Asian risk variants among PD patients varies substantially across studies, with the frequency of p.G2385R reportedly ranging from 7.5% among Chinese patients in Singapore17 to 18.6% in a small study in eastern China18, and p.R1628P ranging from 3.018 to 8.4%19 in eastern China and Singapore, respectively. Here, LRRK2 is linked to Parkinson disease.