Besides, TREM2 leads to macrophages polarizing towards M2 phenotype and paucity of M1-like TAMs, therefore constructing an immunosuppressive TME, as M2-like TAMs expressing anti-inflammatory cytokines and chemokines, which decrease CD8+ T cell activation and enhance Treg recruitment, and contribute to tumor immune evasion [36]. This evidence concerns the gene TREM2 and neoplasm.