LC-TPIT primarily includes genes implicated in Cushing syndrome (e.g., POMC, EGFR), and LC-SF1 is enriched for components of the GnRH signaling pathway (e.g., LHB, FSHB) (Fig. 5g and Supplementary Fig. 5e). This evidence concerns the gene GNRH1 and Cushing syndrome due to macronodular adrenal hyperplasia.