LC-TPIT primarily includes genes implicated in Cushing syndrome (e.g., POMC, EGFR), and LC-SF1 is enriched for components of the GnRH signaling pathway (e.g., LHB, FSHB) (Fig. 5g and Supplementary Fig. 5e). Here, POMC is linked to Cushing syndrome due to macronodular adrenal hyperplasia.