GH1 and neoplasm: We then computed a secreted score based on the average gene expression levels of these proteins (Fig. 5c), and observed that terminally differentiated tumor cells, such as those in Lineage_PIT1_3 (PRL), Lineage_PIT1_4 (GH1), Lineage_TPIT_2, and Lineage_SF1_3, exhibited significantly higher secreted scores compared to earlier or intermediate cells (e.g., Lineage_undiff_1) (Fig. 5d).