EGFR and Cushing syndrome due to macronodular adrenal hyperplasia: LC-TPIT primarily includes genes implicated in Cushing syndrome (e.g., POMC, EGFR), and LC-SF1 is enriched for components of the GnRH signaling pathway (e.g., LHB, FSHB) (Fig. 5g and Supplementary Fig. 5e).