GUCY1B1 and hypertrophic cardiomyopathy: We also observed enrichment in pathways associated with circadian entrainment (e.g., GNG11, GUCY1B1) and hypertrophic cardiomyopathy (e.g., ITGB3, ITGA2B, IL6), suggesting systemic disruptions in PitNET PBMCs (Fig. 1e).