SPMIP8 and cancer: TEPP-46, a small molecule, induces Pkm2 tetramer formation, impairs Pkm2 accumulation, alters the glycolytic status of cancer cells, and xenografts of cancer cells are prevented from growing.45 Damasceno and colleagues demonstrated that nuclear Pkm2 exists as a dimer, whereas the tetrameric form of Pkm2 localizes to the cytoplasm.46 We constructed a PCOS-like mouse model as described previously.8 Mice were administered TEPP-46 every other day for 4 weeks immediately after dehydroepiandrosterone (DHEA) treatment (Fig. 6a).