KCNH7 and obesity due to melanocortin 4 receptor deficiency: In a genome-wide association study, among the five identified susceptible sites in PCOS, the KCNH7/FIGN locus (chr2 q24.2–q24.3) was found to be linked to the metabolic subtype.13 In a phenome-wide association study, Joo and colleagues reported a correlation between the PCOS polygenic risk score and obesity and obesity-related phenotypes.14 In addition to symptoms of metabolic disorders, patients with PCOS have abnormal metabolite levels in the ovarian microenvironment.