PKM and polycystic ovary syndrome: In particular, the nuclear localization of PKM2 (nPKM2) induces the expression of several prominent PCOS-related genes, including CYP11A1 and CYP17A1. TEPP-46, which promotes the formation of a tetramer of PKM2 and thereby blocks its nuclear translocation, effectively prevents the onset of the PCOS-like phenotype in mouse models.