While our findings demonstrate that TEPP-46 has an effective effect on the DHEA-induced model, we agree that its impact on genetic PCOS models (e.g., Pten knockout or Cyp17a1 ectopic expression mice) remains untested and is an important research field.63,64 TEPP-46 rescued DHEA-induced PCOS phenotypes, but its applicability to other subtypes (e.g., genetic or insulin-dominant PCOS) requires further study. Here, INS is linked to polycystic ovary syndrome.