Genotypic analysis in 32 cases with fatal COVID‐19 after infection with the ancient SARS‐CoV‐2 revealed that 7 individuals (22%) were homozygous for the APOE4 allele (APOE4/E4), 11 patients (34%) were heterozygous (APOE3/E4), and the remaining 14 cases (44%) were homozygous for the APOE3 allele (APOE3/E3) (Figure 2A). This evidence concerns the gene APOE and COVID-19.