Accordingly, Apoe−/− mouse mutants carrying a mutation in Slc40a1 associated with the autosomal dominant form of iron overload known as type IV haemochromatosis, show increased number and area of aortic atherosclerotic lesions, higher levels of oxidised low-density-lipoprotein (LDL) and increased EC dysfunction [79]. The gene discussed is SLC40A1; the disease is Tangier disease.