We acknowledge that our experimental model is limited by the use of pharmacological tools and further validation using genetic models is required to prove that ABCB8 suppresses iron-dependent TGF-β-mediated vascular inflammation and the role of the ABCB8-iron-TGF-β axis in atherosclerosis, hypertension and in the transcriptional reprogramming of cell populations within the aortic wall. Here, TGFB1 is linked to hypertensive disorder.