KEGG pathway enrichment further indicated significant involvement in critical signaling pathways, among the top 10 enriched pathways including Herpes simplex virus 1 infection, Prion disease, Salmonella infection, transcriptional misregulation in cancers, cytokine–cytokine receptor interaction, TNF signaling pathway, EGFR tyrosine kinase inhibitor resistance, NOD‐like receptor signaling pathway, cell cycle, TGF‐beta signaling pathway, et al. This evidence concerns the gene TNF and prion disease.