ATG3 and infection: The observations that atg-3 mutants C. elegans phenocopy rde-1 mutants in the transcriptional response to infection as well as in post-entry regulation, and that atg-3; rde-1 double mutants did not exhibit any additional enhanced viral replication (Figs 4 and 5) led us to question whether atg-3 mutant C. elegans could have an RNAi defect.