Results showed that the biocarta caspase pathway (Fig 5D), il18 signaling pathway (Fig 5E), signaling by rho gtpases (Fig 5F), nod like receptor mapk6, mapk4 signaling(Fig 5G), nod like receptor signaling pathway (Fig 5H), and other biologically related pathways were up-regulated in the sepsis group. This evidence concerns the gene IL18 and Sepsis.