In the DKD cohort, after additional adjustment for Log-REN and Log-AII (Model 2), a 100% increase in Log-ALD was associated with a 0.143 nmol/L higher CP (95% CI: 0.002 ~ 0.283, p = 0.047) and a 15.8% higher HOMA-IR (95% CI: 2.5% ~ 29.0%, p = 0.020). This evidence concerns the gene CP and diabetic kidney disease.