CDK4 and neoplasm: As a result, the decrease in tumor size upon NR was also partially rescued in the Cdk4/CycD-overexpressing condition compared to mCherryRNAi control (Fig 2Q′–2T′ and 2V, the size of tumor is reduced by 63% upon NR in mCherryRi, and 18% in Cdk4OE, CycDOE, statistical assessment described in Materials and methods).