AKT1 and neoplasm: Additionally, temporal activation of the PI3K effector AKT (myrAKT) resulted in a smaller reduction in both glial number and tumor size under NR compared to Fed (Fig 5S–5U, the number of glia and tumor size are reduced by 73% and 77%, respectively, upon NR in mCherryRi, and by 25% and 25% in myrAKTOE, statistical assessment described in Materials and methods).