USP22 and breast cancer: Consistent with our observations in human breast cancers, IHC staining of EZH2, USP22, β2M, and CD8+ in serial tissue sections in human prostate and colon cancer tissue microarrays confirmed the increased expression of USP22 and EZH2 in tumors compared with benign tissues (Figure 5, D–G, Supplemental Figure 11, A and B, and Supplemental Figure 12, A and B).