Conversely, further analysis of surviving tumor cells 48 hours after cocultivation with OT-I CD8+ T cells showed a higher USP22 and EZH2, but not EZH1 and USP27 expression (Figure 4I), implying that the increased USP22 and EZH2 expression is involved in tumor immune evasion. This evidence concerns the gene EZH2 and neoplasm.