In addition, consistent with our findings in breast, prostate, and colon cancers (Figure 5 and Supplemental Figures 10–12), tumoral USP22 and EZH2 protein expressions exhibited a strong positive correlation, and both were inversely correlated with tumoral β2M expression and with CD8+ T lymphocytes infiltration in lung cancer (Figure 6, F and G). Here, USP22 is linked to malignant colon neoplasm.