The increased tumor suppression by Usp22 deletion is associated with increased tumor cell surface H-2Kb and β2M expression (Supplemental Figure 3D and Supplemental Figure 4E), the elevated tumoral-infiltrating CD8+ T cells (Supplemental Figure 3, E and F, and Supplemental Figure 4, F and G) and their production granzyme B, IFN-γ, and TNF-α (Supplemental Figure 3, G–I, and Supplemental Figure 4, H–J). Here, GZMB is linked to neoplasm.