Meanwhile, the immunofluorescence (IF) results also indicated much more weakened m6A signals in EZH2-deficient PCa cells as compared with control cells (Figure 1E and Supplemental Figure 1A; supplemental material available online with this article; https://doi.org/10.1172/JCI195840DS1), further supporting our conclusion. Here, EZH2 is linked to posterior cortical atrophy.