As revealed in Figure 2, J and K, and Supplemental Figure 2, J and K, when dCas13b-YTHDF1N was recruited to target METTL14 or WTAP mRNAs by gRNAs, the reduced protein level of these 2 m6A writers in YTHDF1-deficient PCa cells could be specifically rescued. The gene discussed is METTL14; the disease is posterior cortical atrophy.