BDNF and Huntington disease: In stem cell-derived neural paradigms from Huntington’s disease (HD) patients alongside in vivo murine models with striatal lesions, X5050 has been illustrated to restore neuronal gene expression by enhancing the expression of key neuronal genes, notably brain-derived neurotrophic factor (BDNF)(Charbord et al. 2013), (Zhao et al. 2017),(Lam et al. 2023).