RESULTS: PST response differentiated our cohort: 96% of PA were detected in the 56/190 patients with always suppressed renin levels during PST, 80% of patients with low-renin HTN were identified among 56/190 subjects with de-suppression of renin from CP to OP and 78/190 with always measurable renin. The gene discussed is REN; the disease is hypertensive disorder.