The cagA(+)/babA2(+)/vacAs1m2 combination was associated with peptic ulcer disease [adjusted odds ratio (aOR)=5.53, 95 % confidence interval (CI) 1.09–28.16, P=0.039] in male patients and chronic gastritis with precancerous lesions (aOR=5.31, 95 % CI 1.23–22.89, P=0.025) in female patients. The gene discussed is S100A8; the disease is chronic gastritis.