S100A8 and peptic ulcer disease: When evaluating each H. pylori virulence gene of cagA, vacA and babA2 separately in multivariable logistic analysis after adjusting age group and gender, no significant association was observed between vacA s1m1, s1m2 or babA2 (+) genes and gastroduodenal diseases; only the cagA (+) gene was associated with an increased odds of peptic ulcer disease.