Thrombosis and associated midzonal to panlobular hepatic necrosis have been reported in wild-type C57BL/6 mice infected with CCHFV but not STAT1−/− or Ifnar−/− immunocompromised mouse infection models, immunocompetent mice infected with mouse-adapted (MA)-CCHFV, or the STAT2−/− hamster CCHFV-infection model (7, –, 9, 20, 28). This evidence concerns the gene IFNAR1 and infection.