These chaperones collectively regulate the conformational maturity of over 400 protein substrates, many of which are regulators of oncogenic transformation, growth, metastasis, and are closely linked to the ten hallmarks of cancer.[1,2] As a result, inhibition of Hsp90 leads to the degradation of Hsp90‐dependent client proteins via the ubiquitin‐proteasome pathway and the disruption of multiple oncogenic pathways. The gene discussed is HSP90AA1; the disease is cancer.