As a demonstration, we compared MYC locus regulation in three cell types with contrasting MYC expression and epigenetic landscapes: Calu3 lung adenocarcinoma cells (aberrantly high MYC expression), GM12878 B-lymphoblastoid cells [15, 42] (high MYC expression), and primary CD14+ monocytes [43, 44] (negligible MYC expression). This evidence concerns the gene MYC and lung adenocarcinoma.