Via integrating the abovementioned highly associated variables into multifactorial model, admission serum ATF3 levels (OR = 1.016; 95% CI:1.008–1.025; VIF = 2.318; p = 0.010), NIHSS score (OR = 1.156; 95% CI = 1.011–1.320; VIF = 2.872; p = 0.005), and hematoma volume (OR = 1.109; 95% CI = 1.010–1.217; VIF = 2.899; p = 0.009) independently predicted poor prognosis of all patients. This evidence concerns the gene ATF3 and hematoma.