When these variables of significant disparity were put into the binary logistic regression module, it emerged that serum ATF3 levels at admission (OR = 1.014; 95% CI: 1.006–1.023; VIF = 2.207; p = 0.015), NIHSS score (OR = 1.272; 95% CI = 1.168–1.383; VIF = 2.621; p = 0.010), and hematoma volume (OR = 1.141; 95% CI = 1.092–1.192; VIF = 2.788; p = 0.011) were independently associated with END appearance of all patients. Here, ATF3 is linked to hematoma.