The entrance of the aforementioned significant variables on univariate analyses into the multifactorial model led to the revelation that admission serum ATF3 levels (β = 0.018; 95% CI = 0.009–0.026; VIF = 1.702; p = 0.004), NIHSS scores (β = 0.148; 95% CI = 0.083–0.212; VIF = 3.034; p = 0.002), and hematoma volume (β = 0.087; 95% CI = 0.026‐0.148; VIF = 3.291; p = 0.008) kept independently related to mRS scores of all patients. Here, ATF3 is linked to hematoma.