INS and obesity due to melanocortin 4 receptor deficiency: The primary reasons for excluding studies at this stage were: (i) hypoxic intervention not entirely in a hypoxic environment (one study); (ii) inclusion of adults with obesity and with other known chronic or acute diseases (one study); (iii) interventions solely focused on hypoxic training, without a normoxic control group (two studies); and (iv) not including cardiometabolic outcomes (i.e. fasting glucose, fasting insulin, HOMA‐IR, ...) (four studies).