PANX1 and cancer: PANX1 is widely understood to promote tumour cell survival in various cancers (Laird and Penuela, 2021), including the proliferation and differentiation of murine neuroblastoma (Wicki-Stordeur and Swayne, 2013; Wicki-Stordeur et al., 2012) and malignancy of human neuroblastoma (Langlois et al., 2023).