Precise control of purinergic signalling via PANX1 is critical in many diverse cell types, including maintaining neural stem cell populations (Wicki-Stordeur and Swayne, 2013; Wicki-Stordeur et al., 2012, 2016), regulating the development of immature neurons (Sanchez-Arias et al., 2020b, 2019), and tumorigenicity and metastasis of several cancers (Penuela et al., 2012; Freeman et al., 2019; Furlow et al., 2015; Di Virgilio et al., 2018). This evidence concerns the gene PANX1 and cancer.