RT‐qPCR analyses performed in control, DM1 and DKO hiPSC‐derived skeletal muscle cells corroborated this finding, with a ΔPSI of 82.8 ± 3.9% in DM1 skeletal muscle cells and an even more pronounced reduction of 97.2 ± 2.6% in DKO skeletal muscle cells, confirming the regulatory influence of MBNL1/2 proteins on SORBS1 splicing (Figures 1b and S1a). Here, SORBS1 is linked to myotonic dystrophy type 1.