LOX and neoplasm: Unlike other members of the LOX family, which focus on “ECM remodeling”, LOXL3 can also participate in tumorigenesis and development by regulating epithelial-mesenchymal transition (EMT), interfering with cell signaling pathways, mediating chemotherapy resistance, and maintaining genomic stability, and shows certain specificity in different tumor types (Laurentino et al., 2019).