To achieve a comprehensive understanding of the function of LOXL3 in the oncogenesis and progression of malignant tumors, it is essential to address the current research limitations: existing studies have primarily focused on the downstream targets of the LOXL3 gene in tumor cell lines, while its upstream regulatory mechanisms and intrinsic degradation pathways remain poorly understood, warranting further investigation. The gene discussed is LOXL3; the disease is cancer.