Importantly, in the cohort described by Block et al., no cases of hemophagocytic lymphohistiocytosis were reported among patients with DOCK11 deficiency, further suggesting phenotypic distinctions between isolated DOCK11 mutations and hemophagocytic lymphohistiocytosis syndromes related to cytotoxic pathway defects [6]. This evidence concerns the gene DOCK11 and hemophagocytic syndrome.