While Chen et al. [12] reported TRIM14-mediated non-canonical NF-κB activation via the p100/p52 axis in colorectal cancer, and Li et al. [13] demonstrated its role in promoting TRAF3 autophagic degradation to activate NF-κB in psoriasis, our study revealed a distinct mechanism. The gene discussed is NFKB1; the disease is psoriasis.