Thiol protease, acts as a molecular switch for apoptosis, necroptosis and pyroptosis; Salmonella infection recruits caspase−8 to the inflammasome and regulates interleukin-1β production; Salmonella Typhimurium sseK3 induces caspase 8 activation and modulates macrophage apoptosis and glycolysis. The gene discussed is CASP8; the disease is Salmonella Infections.