BDNF and Alzheimer disease: BDNF (hazard ratio [HR] = 0.69, FDR-adjusted p = 2.47 × 10−2), KLK6 (HR = 0.67, FDR-adjusted p = 2.47 × 10−2), NPTXR (HR = 0.65, FDR-adjusted p = 2.47 × 10−2), TAFA5 (HR = 0.70, FDR-adjusted p = 2.92 × 10−2), and FLT1 (HR = 0.72, FDR-adjusted p = 3.07 × 10−2, Fig. 6A–B, Supplementary Table 8) exhibited significant protective associations, indicating their potential roles in reducing the risk of developing symptomatic AD when accumulated.