Fourth, although this panel included high-relevant proteins that capture AD (p-tau217, p-tau181, p-tau231, Aβ40), synuclein pathologies (SNCA, Oligo-SNCA, pSNCA-129, SNCB, TDP43) and general neurodegeneration (NEFL, NRGN, GFAP, TREM2), it is not clear if these 120+ proteins can capture all the pathways and features implicated on these complex diseases. The gene discussed is SNCA; the disease is Alzheimer disease.