These pathways were, in general, shared across all neurodegenerative diseases, even though the major overlap was found for the synaptic functions (BDNF, CCL2, ACHE, GFAP, NEFH or NEFL) and microglia pathways (TREM2, IL13, IL6R IFNG). This evidence concerns the gene TREM2 and neurodegenerative disease.