APP and Alzheimer disease: The main sub-pathway for the Membrane Microdomains was membrane raft (FDR-adjusted p < 1.70 × 10−2; Supplementary Table 9), that included known proteins implicated in AD (APP, TREM2), PD (PARK7), and FTD (MAPT), as well as novel proteins identified in this study related to endothelial health ICAM1, TNF, KDR among others (Supplementary Table 9).