[37]When comparing PD and DLB, we identified 24 proteins with discordant effect sizes (Supplementary Table 2, Supplementary Fig. 4), including p-tau217, p-tau231, p-tau181, ACHE, and MAPT that showed opposite direction between DLB (positive) and PD (negative).(Fig. 2L) PARK7 showed positive effect size in PD but no association with DLB, whereas FLT1 shower higher negative effect size in PD than DLB. Here, ACHE is linked to Parkinson disease.