APOE and Alzheimer disease: Our analysis also highlighted other well-known AD-associated proteins involved in AD-related pathways, including full-length MAPT, APOE, PSEN1, and BACE1, as well as proteins reported to be associated with AD previously in some large-scale proteomics studies, including NPTXR, ACHE, BDNF, IL7, VEGF-D, and VEGF-A [36–38].