In a 2025 multicenter cohort study, Zeng et al. [76] identified a panel of ferroptosis-associated proteins, including ACSL4, GPX4, and prostaglandin-endoperoxide synthase 2 (PTGS2), which were significantly correlated with sepsis severity and 28-day mortality in intensive care unit (ICU) patients. This evidence concerns the gene ACSL4 and Sepsis.