Pharmacological inhibition of ferroptosis has shown promise in reversing immune paralysis, as administration of ferroptosis inhibitors Lip-1 or Fer-1 in murine models of late-stage sepsis demonstrates protective benefits to restore CD8+ T cell function, enhance bacterial clearance, and improve survival, highlighting ferroptosis as a potential therapeutic target for sepsis-induced immunosuppression [110, 116, 171]. This evidence concerns the gene CD8A and Sepsis.