Similarly, yes-associated protein 1 (YAP1) protected the liver from sepsis-induced hepatic damage by inhibiting ferritinophagy-mediated ferroptosis, while knockout of YAP1 aggravated liver damage in septic mice, leading to a reduction in the expression of key ferroptosis regulatory molecules such as SLC7A11 and GPX4, thereby promoting ferritin degradation and further exacerbating ferroptosis and liver damage [186]. The gene discussed is GPX4; the disease is Sepsis.