Similarly, LNPs encoding TCEs such as B7H3 x CD3 (tested in melanoma and other solid tumors) [87], CD19 x CD3, and GPC3 x CD3 (evaluated in hepatocellular carcinoma) [88] exhibited prolonged protein expression, improved tumor control, and reduced dosing frequency compared to recombinant proteins in both murine and non-human primate models. The gene discussed is CD19; the disease is neoplasm.