NLRP3 and Alzheimer disease: IHC demonstrated that compared with WT mice, NLRP3, GSDMD‐N, and Cleaved Caspase‐1 expression in the hippocampal CA1 region of AD mice was significantly increased, while AET led to reductions in the expression of NLRP3, Cleaved Caspase‐1, and GSDMD‐N, which are associated with inflammasome activation and pyroptosis, in the hippocampal CA1 region (Figure 1F, all p < 0.01).