Western blot analysis revealed that ratios of p‐PERK/PERK and p‐eIF2α/eIF2α in the AD group were significantly increased relative to those in the WT group, while the AET group had lower ratios of p‐PERK/PERK and p‐eIF2α/eIF2α than the AD group. This evidence concerns the gene EIF2AK3 and Alzheimer disease.