APP and Alzheimer disease: Given that AD is a progressive disease, assessing the long‐term effects of AET is critical to determine its therapeutic potential; (2) Referring to previous studies [13, 15], male mice were selected for this study, and the effect of sex differences on the neuroprotective effect of AET was not systematically evaluated; (3) Only one AD mouse model (APP/PS1 double‐transgenic mice) was selected for the study.