To explore whether AET exerts its effects through the ERS‐autophagy pathway, we further examined the expression of ERS‐related genes GRP78/Bip, ATF4, and CHOP, as well as autophagy‐related genes Beclin1, LC3‐II, LC3‐I, and P62 in the hippocampal CA1 region of AD mice by Western blot. The gene discussed is HSPA5; the disease is Alzheimer disease.