To investigate the association between TP53 mutations and platinum resistance in OC, we profiled TP53 mutations in 96 high-grade serous ovarian cancer (HGSOC) tumor samples, stratified into four groups: primary sensitive (PS), primary resistant (PR), relapsed sensitive (RS), and relapsed resistant (RR) (Fig. 1A; Details in “Methods”). The gene discussed is TP53; the disease is ovarian serous adenocarcinoma.