While IL7/IL7R signaling was primarily associated with STAT5 activation, emerging reports and our findings indicated that STAT1 could also be engaged [55], imparting a dual function: although classically a tumor suppressor, STAT1 has been implicated in chemoresistance [56, 57] and immune evasion through induction of factors such as PD-L1 [58, 59] and ROS-scavenging proteins [60]. The gene discussed is CD274; the disease is neoplasm.