In this study, we have investigated the role of the IRE1α/XBP1 arm of the UPR in the regulation of skeletal muscle mass in the KRASG12D P53R172H Pdx-Cre+/+ (KPC) mouse model of pancreatic cancer cachexia (Michaelis et al, 2017). This evidence concerns the gene XBP1 and familial pancreatic carcinoma.