Similar to muscle-specific Xbp1-knockout mice, treatment with 4μ8C diminishes the expression of various components of the UPS, autophagy, fatty acid metabolism, oxidative stress, and STAT3 phosphorylation in skeletal muscle of KPC tumor-bearing mice, further suggesting that sXBP1 promotes muscle wasting during cancer cachexia through the activation of proteolytic systems, fatty acid oxidation, and STAT3 signaling (Fig. 8). Here, STAT3 is linked to neoplasm.