P2, a second-degree cousin of P1, presented with recurrent fevers and ANA-positive psoriatic arthritis, unresponsive to treatment with methotrexate and etanercept, but also concurrently exhibits chronic rhinitis and recurrent upper respiratory tract infections, while her mother, who carries the variant, shows very mild symptoms characterized by chronic rhinitis, recurrent upper respiratory tract infections, transient paraesthesia in the lower limbs. The gene discussed is BTG3; the disease is Recurrent upper respiratory tract infections.