BRCA1 and breast cancer: A comprehensive meta-analysis by Chen et al. examining 46,870 breast cancer patients across 16 studies demonstrated a strong association between BRCA1 mutations and TNBC, with BRCA1 mutation carriers showing 8.889-fold increased odds of developing TNBC compared to non-carriers (95% CI 6.925–11.410) and 3.292-fold increased odds compared to BRCA2 mutation carriers (95% CI 2.773–3.909).