In the southern regions of China, the mutation types of β-thalassemia have certain regional characteristics and the more common mutations include CD41-42 (-CTTT), −28 (A >G), CD17 (AAG >TAG), CD26 (GAG >AAG), IVS-II-654 (C >T), and CD71-72 (+ A) [4, 5].These six mutations account for over 90% of all mutation types and represent the primary genetic background of β-thalassemia in the region. The gene discussed is PPIB; the disease is thalassemia.