SYK and infection: During infection of macrophages by C. albicans, pro-IL-1β transcription is regulated through both TLR2/MyD88 and CLR/Dectin-1/SYK pathways, activating the downstream CARD9/BCL10/MALT1 complex that is essential for IL-1β secretion (Fig. 4) (Hise et al, 2009).