SYK and infection: During macrophage infection by A. fumigatus, simultaneous engagement of both CLRs/Dectin-1 or 2/SYK pathway and TLRs (-2, -3, -4, and 9)/MyD88 pathway is required to mediate the priming of inflammasome activation (Fig. 4) (Briard et al, 2019; Karki et al, 2015; Saïd-Sadier et al, 2010).