PIK3C2A and Nephropathy: Global Fth deletion was associated with the development of multiorgan damage, as illustrated serologically by the accumulation of alanine aminotransferase (ALT; liver damage) (Fig. EV2A,B), aspartate aminotransferase (AST; liver damage) (Fig. EV2A,C), lactate dehydrogenase (LDH) (Fig. EV2A,D), creatinine phosphokinase (CPK; muscle damage) (Fig. EV2A,E) and urea (kidney damage) (Fig. EV2A,F) in the plasma of FthR26Δ/Δ⇨FthR26Δ/Δ chimeras vs. control Fth-competent Fthfl/f/Fthwt/wt⇨Fthfl/fl chimeras.